Mastelli polynucleotides: what sets them apart, and why Plinest when it comes to PNT?

In recent years, polynucleotides (PN) have become one of the most dynamically developing areas of medical aesthetics. The skin quality-enhancing and regenerative effects of fish-derived DNA fractions now rest on a professional consensus – but the final result depends greatly on the purity and quality of the raw material. On this question, the Italian company Mastelli has been a point of reference for decades.

One manufacturer, seven decades of experience

Mastelli was founded in 1952 in Sanremo, Italy, and has specialised from the outset in naturally derived, biological active ingredients and dermatological preparations. More than seventy years of pharmacological development experience is no marketing claim: the company keeps the entire supply chain – from raw material selection to the finished medical device – under its own control, which is a critical quality issue in the case of polynucleotides.

The PN-HPT™ technology

The manufacturer's signature is the patented PN-HPT™ (Polynucleotides Highly Purified Technology) process. Its essence is the exceptionally careful extraction and purification of polynucleotides from a natural biological source – in Mastelli's case, trout gonadal DNA. The aim of the highly purified fraction is to maximise the therapeutic effect while minimising the risk of adverse reactions arising from impurities.

The professional foundation of PN-HPT™ is also supported by a dedicated international consensus document discussing its use in aesthetic medicine. Its mechanism of action is multi-layered: polynucleotides have fibroblast-stimulating, free radical-scavenging and powerful hydrating effects, supporting tissue regeneration and the skin's own collagen production.

The product family

The Mastelli portfolio covers the various indications and skin areas in a targeted way:

1. Plinest – maintaining youthful skin condition, remodelling fibrotic areas (e.g. acne scars)
2. Plinest Eye – treating fine lines, dark circles and periocular puffiness
3. Plinest Hair – hair and eyebrow revitalisation, improving scalp condition
4. Plinest Fast – rapid hydration for sensitive skin and post-procedure care
5. Plinest One – treating early skin laxity in younger patients
6. Newest – a polynucleotide + hyaluronic acid combination for mature, dehydrated skin
7. Newest One – intensive treatment for severe atrophic scars and stretch marks

So what makes this manufacturer special?

Mastelli's strength rests on three pillars: decades of pharmaceutical development expertise, its own patented purification process, and control over the entire supply chain. Its products are CE-marked medical devices, manufactured in compliance with GMP and ISO standards. The preparations can also be combined excellently with other aesthetic procedures – laser and radiofrequency treatments, dermal fillers or microneedling – accelerating tissue healing and improving skin quality.